Asymmetric total synthesis of (+)-indatraline via diastereoselective amination of chiral ethers using chlorosulfonyl isocyanate
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چکیده
A concise asymmetric total synthesis of (þ)-indatraline from readily available cinnamic acid is described. The key steps include Corey’s oxazaborolidine-catalyzed asymmetric carbonyl reduction and a highly stereoselective amination of chiral benzylic ether with retention of stereochemistry using chlorosulfonyl isocyanate. 2013 Elsevier Ltd. All rights reserved.
منابع مشابه
Regioselective and diastereoselective allylic amination using chlorosulfonyl isocyanate. A novel asymmetric synthesis of unsaturated aromatic 1,2-amino alcohols.
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Article history: Received 13 December 2010 Revised 1 February 2011 Accepted 9 February 2011 Available online 13 February 2011
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تاریخ انتشار 2013